Effect of allogenic cortical ring packed with autogenous cancellous bone in the reconstruction of rabbit cervical vertebra defects

doi:10.3969/j.issn.2095-4344.2013.51.001

Abstract

Abstract:

BACKGROUND: Vertebral reconstruction is still a challenge for spinal surgeons. Ideal reconstruction materials should have good osteogenesis ability, reliable support performance, low price and simple operating steps.
OBJECTIVE: To investigate the effect and feasibility of allogenic cortical ring packed with autogenous cancellous bone in the reconstruction of rabbit cervical vertebra defect.
METHODS: Cervical vertebra defect models were established by resection of the fourth cervical vertebra in rabbits. Frozen-dried humeral cortical ring of rabbits was made to prepare the allogenic cortical ring which was packed with autogenous cancellous bone. Then, allogenic cortical ring packed with autogenous cancellous bone, single allogenic cortical ring and autogenous iliac bone were used to repair rabbit cervical vertebra defects.
RESULTS AND CONCLUSION: The X-ray, histopathological examination, and scanning electron microscope examinations all showed that the bone union was most significant in group reconstructed with allogenic cortical ring packed with autogenous cancellous bone. The alkaline phosphates activity in serum was higher in groups reconstructed with allogenic cortical ring packed with autogenous cancellous bone and with autogenous iliac bone than in group reconstructed with only allogenic cortical ring at 2 and 4 weeks after operation (P < 0.01), but there was no difference between the former two groups. The biomechanical examination showed that the stability of allogenic cortical ring packed with autogenous cancellous bone was higher than that of autogenous iliac bone at 1 month after operation (P < 0.01). These findings indicate that the effect of allogenic cortical ring packed with autogenous cancellous bone in the reconstruction of rabbit cervical vertebra defects is satisfactory, with a good biocompatibility, which is a promising method for the reconstruction of vertebral defects.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: cervical vertebrae, ilium, biomechanics, alkaline phosphatase, bone remodeling

CLC Number:

R318

Ming Jiang-hua, Zheng Hui-feng, Zhou Jian-lin, Zhou Jian-peng, Zhou Pang-hu. Effect of allogenic cortical ring packed with autogenous cancellous bone in the reconstruction of rabbit cervical vertebra defects [J]. Chinese Journal of Tissue Engineering Research, 2013, 17(51): 8781-8787.

Figures/Tables 4

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